Climate Change and Zoonoses: Disease Pathogens, Vectors and Hosts
In the next decades, the planet will see significant climate changes defined by more severe weather events, including increased warmth, rainfall, heat, droughts, as well as more frequent and powerful...
Pressure ulcers are lesions caused by unrelieved pressure that result in underlying tissue damage. They usually develop over bony prominences below the waist but they can occur anywhere (e.g., in…the nares of patients with nasogastric tubes, in the corners of the mouth in patients with endotracheal tubes, between fingers in patients with rheumatoid arthritis). The prevalence of pressure ulcers in acute care hospitals is about 3-15%, in elderly post-hip fracture patients at least 33% …
Paget’s disease of bone (osteitis deformans) is a disorder of bone metabolism where accelerated bone remodeling at focal locations results in bony overgrowth and impaired bone microarchitecture. First described in…1877 by Sir James Paget, Paget’s disease is primarily a condition whereby excessive osteoclastic bone resorption is followed by excessive bone formation. In asymptomatic presentations, diagnosis is made by elevated bone serum alkaline phosphatase or by incidental findings of plain radiographs obtained for other reasons. Symptomatic patients present with pain…
Only poisonous snakes from the Crotalinae subfamily (pit vipers) and the coral snake from the Elapidae family are native to North America. But countless varieties of non−native snakes are brought…into the United States by collectors and zoos―both legitimate and not. Many of these collections contain exotic snakes such as cobras and vipers, for which antivenoms may be difficult or impossible to obtain.
The North American pit vipers include species of the Crotalus and Sistrurus genera (rattlesnakes) and two from…
Authors:
Thomas C. Arnold, M.D., and Robert A. Barish, M.D., M.B.A.
Dr. Semenza will discuss the unapproved use of adenoviral HIF-1α/VP-16 gene therapy for critical limb ischemia.
Oxygen is essential for human survival. Complex circulatory and respiratory systems have evolved to continuously…deliver adequate O2 to every cell in the body. The development of these systems and their proper utilization are dependent upon the activity of hypoxia-inducible factor 1 (HIF-1), a master regulator protein that controls the transcription of hundreds of genes according to changes in cellular PO2. Alterations in oxygen homeostasis…
Most anesthetics are of a variety of shapes and sizes but are not very large molecules, so their overall binding motifs to proteins, in general, should be somewhat limited. …In our initial studies, we set out to describe the general binding motifs of anesthetics to proteins in several well described anesthetic-protein complexes. There have been several detailed studies of anesthetic-protein complexes that demonstrated direct binding of an anesthetic to a protein. They include bromoform-luciferase, halothane-albumin, halothane-cholesterol oxidase…
Mind body medicine, as defined by the National Center for Complementary and Alternative Medicine (NCCAM) "focuses on the interactions among the brain, mind, body, and behavior, and the powerful ways…in which emotional, mental, social, spiritual, and behavioral factors can directly affect health." Mind body medicine is one of the five major domains of complementary and alternative medicine (medicine that has not been incorporated into the standard of care), and mind body therapies are some of the most…
