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Oxygen Homeostasis in Health and Disease

Dr. Semenza will discuss the unapproved use of adenoviral HIF-1α/VP-16 gene therapy for critical limb ischemia. Oxygen is essential for human survival. Complex circulatory and respiratory systems have evolved to continuously...
CME credit is no longer available for this conference.

Course Authors

Gregg L. Semenza, M.D., Ph.D.

Dr. Semenza is Director of the Vascular Program in the Johns Hopkins Institute for Cell Engineering and Professor in the Deparments of Pediatrics, Medicine, Oncology, Radiation Oncology and McKusick-Nathans Institute of Genetic Medicine at the Johns Hopkins University School of Medicine.

Within the past three years, Dr. Semenza has served as a consultant to Cell Therapeutics Inc., EntreMed Inc., Johnson & Johnson Pharmaceutical Services, Merck and Company, Novartis Pharmaceuticals and Threshold Pharmaceuticals. Under a licensing agreement between Genzyme Corporation and the Johns Hopkins University, Dr. Semenza is entitled to a share of fees received by the University from sales of HIF-1a gene therapy technology that is described in this review. Terms of this arrangement are managed by the University in accordance with its conflict-of-interest policies.

Albert Einstein College of Medicine, CCME staff and interMDnet staff have nothing to disclose.

Estimated course time: 1 hour(s).

Albert Einstein College of Medicine – Montefiore Medical Center designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

In support of improving patient care, this activity has been planned and implemented by Albert Einstein College of Medicine-Montefiore Medical Center and InterMDnet. Albert Einstein College of Medicine – Montefiore Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Learning Objectives

Upon completion of this Cyberounds®, you should be able to:

  • Discuss the molecular mechanisms by which changes in cellular PO2 are sensed and transduced to changes in gene expression through the activity of HIF-1

  • Discuss the role of HIF-1 and its downstream gene products in mediating adaptive responses to tissue ischemia and relevant translational research

  • Discuss the role of HIF-1 in the pathogenesis of cancer and relevant translational research.



The opinions expressed herein are those of the authors and do not necessarily represent the views of the sponsor or its publisher. Please review complete prescribing information of specific drugs or combination of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.


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