Edward J. Bertaccini, M.D.
Release Date: 01/15/2007
Upon completion of this Cyberounds®, you should be able to:
Describe a brief history of the study of anesthetic mechanisms, from lipid theories to more modern protein theories of anesthetic action
Summarize the Meyer-Overton correlation and hypothesis, the exceptions to the Meyer-Overton correlation, the evidence for direct interactions of anesthetics with proteins
Discuss the amphipathic nature of the anesthetic binding site identified within several protein complexes
Discuss the theoretical construct of modern models of ligand-gated ion channels and their relationship to an anesthetic site of action.