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The Molecular Basis of Anesthesia: Recent Advances in Our Understanding

A significant focus of anesthetic action lies within the family of ligand-gated ion channels.
CME credit is no longer available for this conference.

Course Authors

Edward J. Bertaccini, M.D.

Dr. Bertaccini is Associate Professor of Anesthesia, Stanford University School of Medicine.

Within the past 12 months, Dr. Bertaccini reports no commercial conflicts of interest.

Estimated course time: 1 hour(s).

Albert Einstein College of Medicine – Montefiore Medical Center designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

In support of improving patient care, this activity has been planned and implemented by Albert Einstein College of Medicine-Montefiore Medical Center and InterMDnet. Albert Einstein College of Medicine – Montefiore Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Learning Objectives

Upon completion of this Cyberounds®, you should be able to:

  • Describe a brief history of the study of anesthetic mechanisms, from lipid theories to more modern protein theories of anesthetic action

  • Summarize the Meyer-Overton correlation and hypothesis, the exceptions to the Meyer-Overton correlation, the evidence for direct interactions of anesthetics with proteins

  • Discuss the amphipathic nature of the anesthetic binding site identified within several protein complexes

  • Discuss the theoretical construct of modern models of ligand-gated ion channels and their relationship to an anesthetic site of action.



This conference may include discussion of commercial products and services.

The opinions expressed herein are those of the authors and do not necessarily represent the views of the sponsor or its publisher. Please review complete prescribing information of specific drugs or combination of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.


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