Edward J. Bertaccini, M.D.
Dr. Bertaccini is Associate Professor of Anesthesia, Stanford University School of Medicine.
Within the past 12 months, Dr. Bertaccini reports no commercial conflicts of interest.
Estimated course time: 1 hour(s).
Albert Einstein College of Medicine – Montefiore Medical Center designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
In support of improving patient care, this activity has been planned and implemented by Albert Einstein College of Medicine-Montefiore Medical Center and InterMDnet. Albert Einstein College of Medicine – Montefiore Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Upon completion of this Cyberounds®, you should be able to:
Describe a brief history of the study of anesthetic mechanisms, from lipid theories to more modern protein theories of anesthetic action
Summarize the Meyer-Overton correlation and hypothesis, the exceptions to the Meyer-Overton correlation, the evidence for direct interactions of anesthetics with proteins
Discuss the amphipathic nature of the anesthetic binding site identified within several protein complexes
Discuss the theoretical construct of modern models of ligand-gated ion channels and their relationship to an anesthetic site of action.