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Lessons In SLE Genetics

Given that there is a strong genetic component underlying SLE, much research effort has been directed to illuminating the specific genetic details. It became evident from murine and human studies...
CME credit is no longer available for this conference.

Course Authors

Chandra Mohan, M.D., Ph.D.

Dr. Mohan is Professor, Department of Internal Medicine (Rheumatology) University of Texas Southwestern Medical School, Dallas.

Within the past 12 months Dr. Mohan reports no commercial conflicts of interest.

Albert Einstein College of Medicine, CCME staff and interMDnet staff have nothing to disclose.

Estimated course time: 1 hour(s).

Albert Einstein College of Medicine – Montefiore Medical Center designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

In support of improving patient care, this activity has been planned and implemented by Albert Einstein College of Medicine-Montefiore Medical Center and InterMDnet. Albert Einstein College of Medicine – Montefiore Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Learning Objectives

Upon completion of this Cyberounds®, you should be able to:

  • Describe how SLE has a genetic basis, and that it is polygenic.

  • Recognize that both common gene polymorphisms and rare genetic variants can both contribute to SLE susceptibility including HLA-MHC II and III, IRF5, ITGAM, TNFAIP3, BANK1, BLK and FCGR2A/3A/3B.

  • Discuss studies indicating that lupus genes might regulate three distinct checkpoints in disease development — adaptive immunity, innate immunity and end-organ inflammation.



The opinions expressed herein are those of the authors and do not necessarily represent the views of the sponsor or its publisher. Please review complete prescribing information of specific drugs or combination of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.


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