Chandra Mohan, M.D., Ph.D.
Dr. Mohan is Professor, Department of Internal Medicine (Rheumatology) University of Texas Southwestern Medical School, Dallas.
Within the past 12 months Dr. Mohan reports no commercial conflicts of interest.
Albert Einstein College of Medicine, CCME staff and interMDnet staff have nothing to disclose.
Release Date: 03/14/2011
Upon completion of this Cyberounds®, you should be able to:
Describe how SLE has a genetic basis, and that it is polygenic.
Recognize that both common gene polymorphisms and rare genetic variants can both contribute to SLE susceptibility including HLA-MHC II and III, IRF5, ITGAM, TNFAIP3, BANK1, BLK and FCGR2A/3A/3B.
Discuss studies indicating that lupus genes might regulate three distinct checkpoints in disease development Af?cAc‚¬Ac€?? adaptive immunity, innate immunity and end-organ inflammation.
