Lessons In SLE Genetics

The heritability of SLE is relatively high.

CME credit is no longer available for this conference.

Chandra Mohan, M.D., Ph.D.

Release Date: 03/14/2011

Upon completion of this Cyberounds^®, you should be able to:

Describe how SLE has a genetic basis, and that it is polygenic.
Recognize that both common gene polymorphisms and rare genetic variants can both contribute to SLE susceptibility including HLA-MHC II and III, IRF5, ITGAM, TNFAIP3, BANK1, BLK and FCGR2A/3A/3B.
Discuss studies indicating that lupus genes might regulate three distinct checkpoints in disease development Af?cAc‚¬Ac€?? adaptive immunity, innate immunity and end-organ inflammation.

Genetic Basis of COVID-19 Susceptibility and Severity

Genetically pinpointing who is most at risk from SARS-CoV-2 and who is likely to get the severest infection.

Authors: Cleo Anastassopoulou, Ph.D., and Athanasios Tsakris, M.D., Ph.D., F.R.C.Path.

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Mitochondria play a prominent role in the initiation of apoptosis, an organism's normal and controlled death of cells.

Authors: Claus Desler, Ph.D., and Lene Juel Rasmussen, Ph.D.

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BRCA1/2 gene mutations are inherited in an autosomal dominant fashion.

Authors: Jennifer Barrick, M.S., C.G.C., Nancie Petrucelli, M.S., C.G.C., and Michael S. Simon, M.D., M.P.H.

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Receptors for sour- and salty-tasting compounds have not been identified, but may be ion channels.

Authors: Hillary L. Shaw, M.D., Cedrick D. Dotson, Ph.D., Steven D. Munger, Ph.D., and Nanette Steinle, M.D.

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Olfaction is determined by the odorant receptors in the olfactory sensory neurons.

Authors: Hanyi Zhuang, Ph.D., and Hiroaki Matsunami, Ph.D.

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