Because Expertise Matters
Join Cyberounds®, an online education community for health professionals Sign Up

Log In

The Genetics of Breast and Associated Cancers

While 5-10% of women with breast cancer have mutations in one of a number of tumor suppressor genes inherited in an autosomal dominant fashion, most breast cancers have somatic genetic...
CME credit is no longer available for this conference.

Course Authors

Jennifer Barrick, M.S., C.G.C., Nancie Petrucelli, M.S., C.G.C., and Michael S. Simon, M.D., M.P.H.

Ms. Barrick is Genetic Counselor, Division of Hematology and Oncology; Ms. Petrucellil is Clinical Assistant Professor, Senior Genetic Counselor/Coordinator, Division of Hematology and Oncology and Population Studies and Prevention Program; Michael S. Simon is Professor of Medicine and Oncology, Division of Hematology and Oncology and Population Studies and Prevention Program; all at the Karmanos Cancer Institute at Wayne State University, Detroit, MI.

Within the past 12 months Jennifer Barrick, Nancie Petrucelli, and Michael S. Simon report no commercial conflicts of interest.

Albert Einstein College of Medicine, CCME staff and interMDnet staff have nothing to disclose.

Estimated course time: 1 hour(s).

Albert Einstein College of Medicine – Montefiore Medical Center designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

In support of improving patient care, this activity has been planned and implemented by Albert Einstein College of Medicine-Montefiore Medical Center and InterMDnet. Albert Einstein College of Medicine – Montefiore Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

 
Learning Objectives

Upon completion of this Cyberounds®, you should be able to:

  • Identify risk factors for breast cancer

  • Describe the principal features of various hereditary breast cancer syndromes

  • List the associated cancers and the risk of developing these cancers for each hereditary breast cancer syndrome

  • Apply management recommendations for each hereditary breast cancer syndrome

  • Recognize the clinical overlap between hereditary breast cancer syndromes, and the importance of a detailed cancer family history.

 

TERMS AND CONDITIONS

The opinions expressed herein are those of the authors and do not necessarily represent the views of the sponsor or its publisher. Please review complete prescribing information of specific drugs or combination of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.

 

Please click below to accept the terms of this CME activity

Courses You Might Like

Genetic Basis of COVID-19 Susceptibility and Severity

The emergence of the second Sarbecovirus in the 21st century has led to a pandemic that has disrupted human society in an unprecedented mode in recent history. More than 80 million people have been infected worldwide by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged in Wuhan, Hubei Province, China in December 2019, while the global death toll of the resulting coronavirus disease 2019 (COVID-19) amounts to over 1.7 million, as of December 30, 2020. A key
Authors: Cleo Anastassopoulou, Ph.D., and Athanasios Tsakris, M.D., Ph.D., F.R.C.Path.
Estimated Time: 1 Hour
More

Mitochondria in Health and Disease

Mitochondria are semiautonomous organelles present in almost all eukaryotic cells in quantities ranging from a single copy to several thousand per cell. Important mitochondrial functions include ATP production by oxidative phosphorylation, ?2-oxidation of fatty acids and metabolism of amino acids and lipids. Furthermore, mitochondria have a prominent role in the initiation of apoptosis (i.e., an organism’s normal and controlled death of cells). Due to their involvement in ATP production, dysfunction of mitochondria is involved in a range of pathologies known
Authors: Claus Desler, Ph.D., and Lene Juel Rasmussen, Ph.D.
Estimated Time: 1 Hour
More

Lessons In SLE Genetics

Given that there is a strong genetic component underlying SLE, much research effort has been directed to illuminating the specific genetic details. It became evident from murine and human studies that SLE is a polygenic disease with multi-factorial origin. More than two dozen genes have been reproducibly and robustly associated with SLE susceptibility, and these can be broadly divided into two categories: (i) common genetic polymorphisms, mostly uncovered through genome-wide association studies (GWAS), and
Authors: Chandra Mohan, M.D., Ph.D.
Estimated Time: 1 Hour
More

Genetic Variation In Taste Receptors and Eating Behavior

Taste perception influences food preference and intake. Sensory inputs from taste receptors provide information regarding the identity and flavor of food. Taste sensations can induce satiety and reinforce eating. Taste bud density, differences in salivary constituents, genetic variation in taste receptors, and exocrine and endocrine factors may all influence food intake and, therefore, influence risk for nutrition-related conditions including obesity, diabetes, cardiovascular disease, hypertension, hyperlipidemia and cancer. There are five widely accepted taste
Authors: Hillary L. Shaw, M.D., Cedrick D. Dotson, Ph.D., Steven D. Munger, Ph.D., and Nanette Steinle, M.D.
Estimated Time: 1 Hour
More

Molecular Mechanisms Underlying Mammalian Olfaction

Olfaction is determined by the odorant receptors (ORs) in the olfactory sensory neurons (OSNs) of the main olfactory epithelium. Mammalian ORs are G protein-coupled receptors (GPCRs) that are expressed on the cell-surface membrane at the tip of the dendrites in the OSNs. ORs, first cloned in 1991 by Buck and Axel, comprise the largest gene family among all GPCRs. Approximately 400 genes are annotated as ORs in humans, whereas more than 1000 genes encode distinct
Authors: Hanyi Zhuang, Ph.D., and Hiroaki Matsunami, Ph.D.
Estimated Time: 1 Hour
More