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Central Nervous System-selective Estrogens: A Safe Estrogen Therapy

Prodrug approach seems to be the most likely to succeed, promising full benefits expected from CNS-selective ET/HT.
CME credit is no longer available for this conference.

Course Authors

Istvan Merchenthaler, M.D., Ph.D., D.Sc. and Laszlo Prokai, Ph.D., D.Sc.

Dr. Merchenthaler is a Professor, Department of Epidemiology & Preventive Medicine and Anatomy & Neurobiology, University of Maryland, School of Medicine, Baltimore, MD; and Dr. Prokai is the Robert A. Welch Professor, Department of Molecular Biology & Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX.

Within the past 12 months Dr. Merchenthaler received grant/research support from Ausio Pharmaceuticals, while Dr. Prokai was involved with AgyPharma, LLC, that he co-founded.

Albert Einstein College of Medicine, CCME staff and interMDnet staff have nothing to disclose.

Estimated course time: 1 hour(s).

Albert Einstein College of Medicine – Montefiore Medical Center designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

In support of improving patient care, this activity has been planned and implemented by Albert Einstein College of Medicine-Montefiore Medical Center and InterMDnet. Albert Einstein College of Medicine – Montefiore Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Learning Objectives

Upon completion of this Cyberounds®, you should be able to:

  • Describe the mechanisms by which estrogen exerts neuroprotective effects

  • List the efforts to develop a safe estrogen therapy without side effects in the uterus and breast

  • Discuss concepts to enable safe, central nervous system-selective estrogen therapy.



The opinions expressed herein are those of the authors and do not necessarily represent the views of the sponsor or its publisher. Please review complete prescribing information of specific drugs or combination of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.


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