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Glucose Sensing in the Central Nervous System

The brain is an obligate glucose consumer and critically dependent on glucose supply for normal function.
CME credit is no longer available for this conference.

Course Authors

Kelly A. Diggs-Andrews, B.S., Julie M. Silverstein, M.D., and Simon J. Fisher, M.D., Ph.D.

Ms. Diggs-Andrews is currently a senior Ph.D. student in the Molecular Cellular Biology program in the Division of Biology and Biomedical Sciences at Washington University in St. Louis; Dr. Silverstein is currently a clinical fellow and Dr. Fisher is currently an Assistant Professor of Medicine, Cell Biology & Physiology, both in the Division of Endocrinology, Metabolism & Lipid Research, Washington University, St. Louis, MO.

Within the past 12 months, Ms. Diggs-Andrews and Dr. Silverstein report no commercial conflicts of interest; Dr. Fisher has been a member of the Speakers Bureau for Merck. This relationship will not influence his presentation.

This activity is made possible an unrestricted educational grant from Merck.

Estimated course time: 1 hour(s).

Albert Einstein College of Medicine – Montefiore Medical Center designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

In support of improving patient care, this activity has been planned and implemented by Albert Einstein College of Medicine-Montefiore Medical Center and InterMDnet. Albert Einstein College of Medicine – Montefiore Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Learning Objectives

Upon completion of this Cyberounds®, you should be able to:

  • Identify the sites in the brain that sense and respond to changes in blood sugar

  • Identify some of the key glucose sensing proteins in the brain

  • Describe the hierarchy of hormones that are released in response to hypoglycemia

  • Discuss the etiology of the impaired counterregulatory response and hypoglycemia unawareness that occurs in people with diabetes

  • List some therapeutic interventions shown to reduce the risk of hypoglycemia.



This conference may include discussion of commercial products and services.

The opinions expressed herein are those of the authors and do not necessarily represent the views of the sponsor or its publisher. Please review complete prescribing information of specific drugs or combination of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.


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