Ogo I. Egbuna, M.D., M.Sc., and Edward M. Brown, M.D.
Dr. Egbuna is a research fellow in the Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, a staff physician in the Department of Medicine, Division of Nephrology, Beth Israel Deaconess Medical Center, and Instructor in Medicine, Harvard Medical School; Dr. Brown is a staff physician in the Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, and Professor of Medicine, Harvard Medical School.
Within the past 12 months, Dr. Brown has been on the Speakers Bureau for Athena Diagnostics and receives royalties from NPS Pharmaceuticals, Inc. Dr. Egbuna reports no commercial conflicts of interest.
Release Date: 07/15/2008
Upon completion of this Cyberounds®, you should be able to:
Describe Ca2+o homeostasis, calcium-sensing receptors (CaSRs) and the role of the prototypical CaSR in Ca2+o homeostasis
Discuss recent advances in our understanding of the structure-function relationships and ligand binding sites of the CaSR
List the spectrum of mutations involving the CaSR that cause human disease and describe disorders arising from anti-CaSR autoantibodies
Discuss the actions of the CaSR in CaSR-expressing tissues in defending against both hypo- and hypercalcemia
Discuss the current and potential utility of CaSR-based therapeutics
Outline future directions in CaSR physiology and research.
