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Extracellular Calcium and Calcium Sensing Receptors: Evolving Perspectives

Extracellular calcium (Ca2+o) is an important divalent mineral ion critical for numerous physiological processes.
CME credit is no longer available for this conference.

Course Authors

Ogo I. Egbuna, M.D., M.Sc., and Edward M. Brown, M.D.

Dr. Egbuna is a research fellow in the Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, a staff physician in the Department of Medicine, Division of Nephrology, Beth Israel Deaconess Medical Center, and Instructor in Medicine, Harvard Medical School; Dr. Brown is a staff physician in the Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, and Professor of Medicine, Harvard Medical School.

Within the past 12 months, Dr. Brown has been on the Speakers Bureau for Athena Diagnostics and receives royalties from NPS Pharmaceuticals, Inc. Dr. Egbuna reports no commercial conflicts of interest.

Estimated course time: 1 hour(s).

Albert Einstein College of Medicine – Montefiore Medical Center designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

In support of improving patient care, this activity has been planned and implemented by Albert Einstein College of Medicine-Montefiore Medical Center and InterMDnet. Albert Einstein College of Medicine – Montefiore Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Learning Objectives

Upon completion of this Cyberounds®, you should be able to:

  • Describe Ca2+o homeostasis, calcium-sensing receptors (CaSRs) and the role of the prototypical CaSR in Ca2+o homeostasis

  • Discuss recent advances in our understanding of the structure-function relationships and ligand binding sites of the CaSR

  • List the spectrum of mutations involving the CaSR that cause human disease and describe disorders arising from anti-CaSR autoantibodies

  • Discuss the actions of the CaSR in CaSR-expressing tissues in defending against both hypo- and hypercalcemia

  • Discuss the current and potential utility of CaSR-based therapeutics

  • Outline future directions in CaSR physiology and research.



This conference may include discussion of commercial products and services.

The opinions expressed herein are those of the authors and do not necessarily represent the views of the sponsor or its publisher. Please review complete prescribing information of specific drugs or combination of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.


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