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Rapid Risk Stratification of Septic Adults in Non-Intensive Care Unit Settings

Severe sepsis is a common, deadly condition, usually caused by an infection (highly suspected or confirmed), which provokes a systemic inflammatory response. The inflammatory response is most commonly defined as the presence of two or more Systemic Inflammatory Response Syndrome (SIRS) Criteria (Table 1). The SIRS criteria are intentionally non-specific so that a large proportion of infected patients can be classified as septic. However, this broad inclusion limits the usefulness of a diagnosis of sepsis in distinguishing a high-risk patient population.
CME credit is no longer available for this conference.

Course Authors

Jeffrey P. Green, M.D.

Dr. Green is Clinical Research Fellow, Department of Emergency Medicine, University of California, Davis School of Medicine, Sacramento, CA.

Within the past 12 months, Dr. Green reports no commercial conflict of interest.

Albert Einstein College of Medicine, CCME staff, and interMDnet staff have nothing to disclose.

Estimated course time: 1 hour(s).

Albert Einstein College of Medicine – Montefiore Medical Center designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

In support of improving patient care, this activity has been planned and implemented by Albert Einstein College of Medicine-Montefiore Medical Center and InterMDnet. Albert Einstein College of Medicine – Montefiore Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Learning Objectives

Upon completion of this Cyberounds®, you should be able to:

  • Describe severe sepsis and discuss the importance of rapid and accurate risk stratification and apply it to the care of patients

  • Discuss currently available clinical risk stratification tools for rapid risk stratification of severe sepsis in non-intensive care unit settings

  • Describe the physiology of lactate metabolism and its implications for use in sepsis risk stratification

  • Supplement clinical risk stratification of severe sepsis by application of inflammatory biomarkers.



The opinions expressed herein are those of the authors and do not necessarily represent the views of the sponsor or its publisher. Please review complete prescribing information of specific drugs or combination of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.


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