Ogo I. Egbuna, M.D., M.Sc.
, and Edward M. Brown, M.D.
Dr. Egbuna is a research fellow in the Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, a staff physician in the Department of Medicine, Division of Nephrology, Beth Israel Deaconess Medical Center, and Instructor in Medicine, Harvard Medical School; Dr. Brown is a staff physician in the Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, and Professor of Medicine, Harvard Medical School.
Within the past 12 months, Dr. Brown has been on the Speakers Bureau for Athena Diagnostics and receives royalties from NPS Pharmaceuticals, Inc. Dr. Egbuna reports no commercial conflicts of interest.
Estimated time to complete:
Albert Einstein College of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™.
Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Albert Einstein College of Medicine is accredited
by the Accreditation Council for Continuing
Medical Education to provide continuing medical
education for physicians.
Upon completion of this Cyberounds®
, you should be able to:
- Describe Ca2+o homeostasis, calcium-sensing receptors (CaSRs) and the role of the prototypical CaSR in Ca2+o homeostasis
- Discuss recent advances in our understanding of the structure-function relationships and ligand binding sites of the CaSR
- List the spectrum of mutations involving the CaSR that cause human disease and describe disorders arising from anti-CaSR autoantibodies
- Discuss the actions of the CaSR in CaSR-expressing tissues in defending against both hypo- and hypercalcemia
- Discuss the current and potential utility of CaSR-based therapeutics
- Outline future directions in CaSR physiology and research.