Bruce S. McEwen, Ph.D.
Dr. McEwen reports no conflict of interest.
This activity is made possible by an unrestricted educational grant from Forest Laboratories.
Estimated time to complete:
Albert Einstein College of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™.
Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Albert Einstein College of Medicine is accredited
by the Accreditation Council for Continuing
Medical Education to provide continuing medical
education for physicians.
Upon completion of this Cyberounds®
, you should be able to:
- Define "allostasis" and "allostatic load" and give examples of each for the metabolic, cardiovascular and immune systems
- Describe the role of excitatory amino acids (EAA) in relation to structural remodeling under stress and how this changes as the brain ages
- Describe how glucocorticoids and EAA interact in relation to damage produced by ischemic and seizures on brain structures like the hippocampus
- Describe why chronic stress may increase or decease vulnerability to insults such as ischemia or seizures.