Bruce S. McEwen, Ph.D.
Dr. McEwen reports no conflict of interest.
This activity is made possible by an unrestricted educational grant from Forest Laboratories.
Estimated time to complete:
Albert Einstein College of Medicine – Montefiore Medical Center designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™.
Physicians should claim only the credit commensurate with the extent of their participation in the activity.
In support of improving patient care, this activity has been planned and implemented by Albert Einstein College of Medicine-Montefiore Medical Center and InterMDnet. Albert Einstein College of Medicine – Montefiore Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Upon completion of this Cyberounds®
, you should be able to:
- Define "allostasis" and "allostatic load" and give examples of each for the metabolic, cardiovascular and immune systems
- Describe the role of excitatory amino acids (EAA) in relation to structural remodeling under stress and how this changes as the brain ages
- Describe how glucocorticoids and EAA interact in relation to damage produced by ischemic and seizures on brain structures like the hippocampus
- Describe why chronic stress may increase or decease vulnerability to insults such as ischemia or seizures.