Bethesda Criteria

1. Individuals with cancer in families that fulfill Amsterdam Criteria.
2. Individuals with two HNPCC-related cancers, including synchronous or metachronous (i.e., arising at a different time) CRCs or associated extracolonic cancers.
3. Individuals with CRC and a first degree relative with CRC and/or HNPCC-related extracolonic cancer and/or colorectal adenoma; one of the cancers diagnosed at <45 y and the adenoma diagnosed at <40 y.
4. Individuals with CRC or endometrial cancer diagnosed at <45 y.
5. Individuals with right-sided CRC with undifferentiated pattern (solid/cribiform) on histopathology diagnosed at <45 y.
6. Individuals with signet-ring-cell type CRC diagnosed at <45 y.
7. Individuals with adenomas diagnosed at <40 y.